Since TPA Operations will be directly debiting my bank account, will I need to set up the TPA as a new vendor in my accounts payable system?

Answer:

No. You do not need to set up a new vendor because you are still making your payments to the parties listed on your invoice via the CGDP Portal. Once you select items for payment on the Portal, the debits are being executed by PNC Bank. PNC is acting as the Originating Depository Financial Institution (ODFI) in the ACH process on the TPA’s behalf to route the payments to the Payees associated with the selected invoice line items.